Journal of Pharmacy Research Vol.1.Issue 1. July-September 2008 Effect of Different Viscosity Grades of HPMC on Drug Release Profile

In this study, different grades of hydroxyl propyl methyl cellulose (HPMC) were used to develop floating microspheres of Cefpodoxime Proxetil in order to demonstrate the effect of different viscosities on drug release profile. The Cefpodoxime Proxetil microspheres were prepared by non aqueous solvent evaporation method using different grades of HPMC such as HPMC K15M ( 15cps), HPMCK4M(4000cps), HPMC100LV(100cps) and ethyl cellulose. The prepared microspheres were characterized by polymer compactibility (FTIR Scan), percentage yield, Buoyancy percentage, Drug Entrapment Efficiency (DEE) and invitro drug release was performed by USP Apparatus type I. The prepared floating microspheres were found to produce the percentage yield of 50.5-72.21%, Drug Entrapment Efficiency of 14.1-28.2%, Buoyancy percentage of 70.1-88.25 % and drug release of microspheres of 65.09-101.88%. The better drug release profile was found to be with formulation (F A2) with drug:polymer ratio of 1:2, HPMC 15cps showed much significant increase in the drug release while comparing with the other two grades of HPMC. Key Words: Floating microspheres, Cefpodoxime Proxetil, HPMC K15,HPMC K4M,HPMC K 100, in vitro release studies, bioavailability