Cytotoxic Potential of various extracts of Lepidium sativum (Linn.)An In-vitro Evaluation

Objective: To explore the cytotoxic activity of seeds of various extract of Lepidium sativum using different cell lines. Methods: The various extracts n-hexane, chloroform, ethyl acetate and methanol extracts of seeds of Lepidium sativum were tested against human cancer cell lines such as human neuroblastoma cell line (IMR‐32), colon cancer cell lines (HT‐15 & HT‐29) and lung cancer cell line A ‐ 549. Results: The result showed that the methanolic extract of Lepidium sativum exhibited a very high degree of in-vitro cytotoxic activity than that of standard mitomycin-c. Similar results were not found in other three extracts. Conclusion: From the result it can be seen that the methanolic extract of Lepidium sativum has potent in-vitro cytotoxic activity