Add to ORKGAbstract: During the formation of breast cancer, many genes become altered as cells evolve progressively from normal to a pre-malignant to a malignant state of growth. How mutations in genes lead to specific subtypes of human breast cancer is only partially understood. Here we review how initial genetic or epigenetic alterations within mammary epithelial cells (MECs) can alter cell fate decisions and put pre-malignant cells on a path towards cancer development with specific phenotypes. Understanding the early stages of breast cancer initiation and progression and how normal developmental processes are hijacked during transformation has significant implications for improving early detection and prevention of breast cancer. In addition, insig...
INTRODUCTION:We have previously identified a rare subpopulation of variant human mammary epithelial ...
SummaryChromosomal instability in human breast cancer is known to take place before mammary neoplasi...
The female mammary epithelium undergoes reorganization during development, pregnancy, and menopause,...
During the formation of breast cancer, many genes become altered as cells evolve progressively from ...
During the formation of breast cancer, many genes become altered as cells evolve progressively from ...
Studies of human mammary epithelial cells from healthy individuals are providing novel insights into...
Studies of human mammary epithelial cells from healthy individuals are providing novel insights into...
The mammary gland has been central to the evolution of mammals by being capable of undergoing multip...
As the most commonly occurring cancer in women worldwide, breast cancer poses a formidable public he...
Individuals carrying deleterious BRCA1 mutations typically develop basal-like rather than luminal br...
Individuals carrying deleterious BRCA1 mutations typically develop basal-like rather than luminal br...
Understanding why BRCA1 mutation carriers have a predilection for developing clinically aggressive b...
The mammary gland undergoes major developmental changes during puberty and pregnancy. It is thought ...
Individuals carrying deleterious BRCA1 mutations typically develop basal-like rather than luminal br...
Changes in the epigenetic landscape are widespread in neoplasia, with de novo methylation and histon...
INTRODUCTION:We have previously identified a rare subpopulation of variant human mammary epithelial ...
SummaryChromosomal instability in human breast cancer is known to take place before mammary neoplasi...
The female mammary epithelium undergoes reorganization during development, pregnancy, and menopause,...
During the formation of breast cancer, many genes become altered as cells evolve progressively from ...
During the formation of breast cancer, many genes become altered as cells evolve progressively from ...
Studies of human mammary epithelial cells from healthy individuals are providing novel insights into...
Studies of human mammary epithelial cells from healthy individuals are providing novel insights into...
The mammary gland has been central to the evolution of mammals by being capable of undergoing multip...
As the most commonly occurring cancer in women worldwide, breast cancer poses a formidable public he...
Individuals carrying deleterious BRCA1 mutations typically develop basal-like rather than luminal br...
Individuals carrying deleterious BRCA1 mutations typically develop basal-like rather than luminal br...
Understanding why BRCA1 mutation carriers have a predilection for developing clinically aggressive b...
The mammary gland undergoes major developmental changes during puberty and pregnancy. It is thought ...
Individuals carrying deleterious BRCA1 mutations typically develop basal-like rather than luminal br...
Changes in the epigenetic landscape are widespread in neoplasia, with de novo methylation and histon...
INTRODUCTION:We have previously identified a rare subpopulation of variant human mammary epithelial ...
SummaryChromosomal instability in human breast cancer is known to take place before mammary neoplasi...
The female mammary epithelium undergoes reorganization during development, pregnancy, and menopause,...