Catovsky D. Splenic lymphoma with villous lymphocytes. Natural history and response to therapy in 50 cases. British Journal of Haematology

Splenic lymphoma with villous lymphocytes (SLVL) is a low-grade disorder that regularly presents with peripheral blood involvement. We describe the immunophenotype of the circulating cells from 100 SLVL patients whose disease has been characterized on clinical, morphologic, and histo-logic grounds. Cells from all cases expressed B-cell anti-gens (CD1 9 and CD37) and/or HLA-Dr and showed light chain restriction (./X: 1.5/1) with moderate to strong inten-sity of membrane lg staining. Cells from most cases (> 80%) were CD24+, FMC7+, and expressed strongly membrane CD22. The monoclonal antibodies CD10, CD23, and CD38 were positive in one-third of the cases; CD1 IC in 47%; and CD25 in 25 % of cases. A minority of cases ( < 20%) were positive with HC2, B-ly-7, and CD5. PLENIC LYMPHOMA with villous lymphocyte