3EVALUATION OF COMMON DOSING REGIMENS FOR MODERATE AND DEEP SEDATION USING A REMIFENTANIL PROPOFOL INTERACTION MODEL FOR RESPIRATORY COMPROMISE

Introduction: Dosing schemes for propofol and propofol in combination with an opiate are commonly used in mildly stimulating procedures of short duration that require moderate to deep sedation. However, some adverse drug effects set in before therapeutic levels of drug are administered. The aim of this simulation study was to evaluate how common dosing regimens for upper endoscopy compare to a pharmacodynamic response surface model for respiratory compromise. We hypothesize that all published dosing regimens will experience a high probability of respiratory compromise