Abstract. We measured telomere lengths of blood leukocytes in several inbred and outbred mammalian species, using a telomere-specific fluorescent probe and flow cytometry. Humans, non-human primates, and three outbred populations of Peromyscus mice (Peromyscus leucopus, Peromyscus maniculatus, and Pero-myscus polionotus) have short telomeres. Two common strains of laboratory mice, C57BL/6J and DBA/2J, have telomeres several times longer than most other mammals surveyed. Moreover, the two inbred laboratory mouse strains display significantly different telomere lengths, suggesting the existence of strain-specific ge-netic determinants. To further examine the effects of inbreeding, we studied three Peromyscus leucopus inbred lines (GS109, GS16...
Telomere length-variation in deletion strains of Saccharomyces cerevisiae was used to identify genes...
Telomere length is a crucial factor for both normal chromosomal function and senescence. Mean telome...
SummaryAutosomal-dominant dyskeratosis congenita is associated with heterozygous mutations in telome...
Telomere length and telomerase activity directly affect the replicative capacity of primary human ce...
BACKGROUND: Telomeres are specialized nucleoprotein structures at chromosome ends that undergo dynam...
Severe combined immunodeficiency (scid) mice are deficient in the enzyme DNA-PK (DNA-dependent prote...
<p>Spleen cells were isolated from C57BL/6, TANK1<sup>+/+</sup> (n = 7) and TANK1<sup>−/−</sup> (n =...
<p>(A) Representative immunofluorescent image of telomeres (depicted by small white circles) using f...
Telomeres play a central role in cellular senescence and cancer pathobiology and are associated with...
Telomere length-variation in deletion strains of Saccharomyces cerevisiae was used to identify genes...
Aberrantly short telomeres result in decreased longevity in both humans and mice with defective telo...
Telomeres are specialized structures at chromosome ends that are thought to function as buffers agai...
<p>(A,B,C) Telomere fluorescence as determined by QFISH in the indicated tissues from the different ...
Leucocytes are typically considered as a whole in studies examining telomere dynamics in mammals. Su...
Reduction of telomere length has been postulated to be a causal factor in cellular aging. Human telo...
Telomere length-variation in deletion strains of Saccharomyces cerevisiae was used to identify genes...
Telomere length is a crucial factor for both normal chromosomal function and senescence. Mean telome...
SummaryAutosomal-dominant dyskeratosis congenita is associated with heterozygous mutations in telome...
Telomere length and telomerase activity directly affect the replicative capacity of primary human ce...
BACKGROUND: Telomeres are specialized nucleoprotein structures at chromosome ends that undergo dynam...
Severe combined immunodeficiency (scid) mice are deficient in the enzyme DNA-PK (DNA-dependent prote...
<p>Spleen cells were isolated from C57BL/6, TANK1<sup>+/+</sup> (n = 7) and TANK1<sup>−/−</sup> (n =...
<p>(A) Representative immunofluorescent image of telomeres (depicted by small white circles) using f...
Telomeres play a central role in cellular senescence and cancer pathobiology and are associated with...
Telomere length-variation in deletion strains of Saccharomyces cerevisiae was used to identify genes...
Aberrantly short telomeres result in decreased longevity in both humans and mice with defective telo...
Telomeres are specialized structures at chromosome ends that are thought to function as buffers agai...
<p>(A,B,C) Telomere fluorescence as determined by QFISH in the indicated tissues from the different ...
Leucocytes are typically considered as a whole in studies examining telomere dynamics in mammals. Su...
Reduction of telomere length has been postulated to be a causal factor in cellular aging. Human telo...
Telomere length-variation in deletion strains of Saccharomyces cerevisiae was used to identify genes...
Telomere length is a crucial factor for both normal chromosomal function and senescence. Mean telome...
SummaryAutosomal-dominant dyskeratosis congenita is associated with heterozygous mutations in telome...