FoXS: a web server for rapid computation and fitting of SAXS profiles

Small angle X-ray scattering (SAXS) is an increas-ingly common technique for low-resolution struc-tural characterization of molecules in solution. SAXS experiment determines the scattering inten-sity of a molecule as a function of spatial frequency, termed SAXS profile. SAXS profiles can contribute to many applications, such as comparing a conformation in solution with the corresponding X-ray structure, modeling a flexible or multi-modular protein, and assembling a macromolecular complex from its subunits. These applications require rapid computation of a SAXS profile from a molecular structure. FoXS (Fast X-Ray Scattering) is a rapid method for computing a SAXS profile of a given structure and for matching of the computed and experimental profiles. Here, we describe the inter-face and capabilities of the FoXS web serve