Author’s Note: The first two authors contribute equally to this article. Zhaoli Song, Nan Wang,

Behavioral genetic studies have revealed that job satisfaction is heritable. However, little is known about what specific genes may be associated with job satisfaction and if so the mechanisms for such associations. In the present study, the experience-sampling method was used to examine the relationship between the-1438A/G SNP in the serotonin 2A receptor gene (5-HT2A), and momentary job satisfaction. A sample of 206 Chinese Singaporeans reported their momentary experiences of job satisfaction and encountered stressors 4 times per day for a period of one week. The G allele in the-1438A/G SNP was associated with lower mean level of momentary job satisfaction across the week as compared with the A allele. Furthermore, we found that major stressful life events as well as momentary stressors demonstrated the strongest negative relationship with momentary job satisfaction among participants with the G/G genotype. These results suggest that the-1438A/G SNP in the 5-HT2A gene may be one form of geneti