Identification of an Adenylyl Cyclase Inhibitor for Treating Neuropathic Editor's Summary

humans, it may prove useful to eliminating seemingly purposeless pain from our lives. If the selective action of NB001 on neuropathic pain and its lack of serious side effects also holds true in pain-related brain region.−hippocampus, a non effect may underlie its analgesic ability, a conclusion consistent with the fact that it does not alter such plasticity in the Thisdorsal horn of the spinal cord and the anterior cingulate cortex to ''learn,' ' a process triggered in neuropathic pain. A clue to how NB001 works can be gleaned from the result that it extinguishes the ability of synapses in the profile of this drug. safetymotor function, and fear all showed that NB001 had no effects on these endpoints, a good sign for the potential affect neurotransmission of the critical hormone glutamate or the size of glutamate-induced currents. Tests of anxiety, not interfere with normal nociception, the sensation that allows the animal to escape dangerous heat. It does not Just as important as these effects of NB001 on chronic pain are the effects that it does not have. NB001 does also prevented allodynia, although to a lesser extent, suggesting that NB001 acts on multiple sites in the body. drug was injected directly into the anterior cingulate cortex (a brain region involved in neuropathic pain generation), it were ligated or in mice with chronic inflammatory pain, produced by an injection of an irritant into a paw. And when the NB001 prevented allodynia (a condition in which an innocuous stimulus causes pain) in mice in which certain nerve