Learning the structure of genetic network dynamics: A geometric approach

Abstract: This work concerns the identification of the structure of a genetic network model from measurements of gene product concentrations and synthesis rates. In earlier work, for a wide family of network models, we developed a data preprocessing algorithm that is able to reject many hypotheses on the network structure by testing certain monotonicity properties of the models. Here we develop a geometric analysis of the method. Then, for a relevant subclass of genetic network models, we extend our approach to the combined testing of monotonicity and convexity-like properties associated with the network structures. Theoretical achievements as well as performance of the enhanced methods are illustrated by way of numerical results