computational proteomics Interlaboratory Study Characterizing a Yeast Performance Standard for Benchmarking LC-MS Platform Performance*□S

Optimal performance of LC-MS/MS platforms is critical to generating high quality proteomics data. Although individ-ual laboratories have developed quality control samples, there is no widely available performance standard of bio-logical complexity (and associated reference data sets) for benchmarking of platform performance for analysis of complex biological proteomes across different laborato-ries in the community. Individual preparations of the yeast Saccharomyces cerevisiae proteome have been used ex-tensively by laboratories in the proteomics community to characterize LC-MS platform performance. The yeast proteome is uniquely attractive as a performance stand-ard because it is the most extensively characterized com-plex biological proteome and the only one associated with several large scale studies estimating the abundance o