REPORT Genome-wide Association of Copy-Number Variation Reveals an Association between Short Stature and the Presence of Low-Frequency Genomic Deletions

Height is a model polygenic trait that is highly heritable. Genome-wide association studies have identified hundreds of single-nucleotide polymorphisms associated with stature, but the role of structural variation in determining height is largely unknown. We performed tu at le n ni su eq ul variation, such as low-frequency variation and/or copy- who had undergone comparative genomic hybridizationThe Americnumber variation, might contribute to the genetic varia-tion in stature. Although there are a few examples of common copy-number variants (CNVs) that are associated with complex traits, such as obesity4 and Crohn disease,5 the data thu