Biofilm dispersal: deciding when it is better to travel

Bacteria live predominantly in biofilms, and the inter-nal signal cyclic diguanylate (c-di-GMP) is a universal signal that governs the formation and the dispersal of these communities. Pseudomonas aeruginosa is one of the most important reference systems for studying bacterial biofilms and contains numerous diguanylate cyclases (DGCs) for synthesizing c-di-GMP and phosphodiesterases (PDEs) for degrading c-di-GMP. However, few studies have discerned how cells in biofilms respond to their environment to regulate c-di-GMP concentrations through this sophisticated network of enzymes. Basu Roy and Sauer (2014) provide insights on how cells disperse in response to an increase in nutrient levels. Their results show that the inner membrane protein NicD is a DGC tha