Dopamine plays an important role in several forms of synaptic plasticity in the hippocampus, a crucial brain structure for working memory (WM) functioning. In this study, we evaluated whether the working-memory impairment characteristic of animal models of chronic pain is dependent on hippocampal dopaminergic signaling. To address this issue, we implanted multichannel arrays of elec-trodes in the dorsal and ventral hippocampal CA1 region of rats and recorded the neuronal activity during a food-reinforced spatialWM task of trajectory alternation. Within-subject behavioral performance and patterns of dorsoventral neuronal activity were assessed before andafter theonset of persistent neuropathic painusing the SparedNerve Injury (SNI)model of n...
Opioids are important endogenous ligands that exist in both invertebrates and vertebrates and signal...
Elucidating the chemical changes that underlie dysfunction of the central nervous system requires to...
Earlier studies indicate that striatal dopamine D-2 receptors are involved in pain regulation in non...
In the current study we focus on the involvement of dopamine D2 receptors in the ventral hippocampus...
Cognitive impairment associated with chronic pain remains relatively poorly understood. Use of analg...
Patients with chronic pain usually suffer from working memory deficits, which may decrease their int...
In constantly changing environments, it is crucial to adaptively respond to threatening events. In p...
Chronic pain represents a substantial burden to society and is difficult to manage for both physicia...
Emerging evidence suggests that the mesolimbic dopaminergic network plays a role in the modulation o...
Chronic pain attenuates midbrain dopamine (DA) transmission, as evidenced by a decrease in opioid-ev...
Background and aims: Although neuropathic pain is known to negatively affect cognition, the neural m...
Recent progress in the pain research field has shed light on the role of dopaminergic neurotransmiss...
In humans, affective consequences of neuropathic pain, ranging from depression to anxiety and anhedo...
Chronic pain is associated with high social and economic costs due to its disabling physical and psy...
Delta opioid receptor (DOR) agonists alleviate nociceptive behaviors in various chronic pain models,...
Opioids are important endogenous ligands that exist in both invertebrates and vertebrates and signal...
Elucidating the chemical changes that underlie dysfunction of the central nervous system requires to...
Earlier studies indicate that striatal dopamine D-2 receptors are involved in pain regulation in non...
In the current study we focus on the involvement of dopamine D2 receptors in the ventral hippocampus...
Cognitive impairment associated with chronic pain remains relatively poorly understood. Use of analg...
Patients with chronic pain usually suffer from working memory deficits, which may decrease their int...
In constantly changing environments, it is crucial to adaptively respond to threatening events. In p...
Chronic pain represents a substantial burden to society and is difficult to manage for both physicia...
Emerging evidence suggests that the mesolimbic dopaminergic network plays a role in the modulation o...
Chronic pain attenuates midbrain dopamine (DA) transmission, as evidenced by a decrease in opioid-ev...
Background and aims: Although neuropathic pain is known to negatively affect cognition, the neural m...
Recent progress in the pain research field has shed light on the role of dopaminergic neurotransmiss...
In humans, affective consequences of neuropathic pain, ranging from depression to anxiety and anhedo...
Chronic pain is associated with high social and economic costs due to its disabling physical and psy...
Delta opioid receptor (DOR) agonists alleviate nociceptive behaviors in various chronic pain models,...
Opioids are important endogenous ligands that exist in both invertebrates and vertebrates and signal...
Elucidating the chemical changes that underlie dysfunction of the central nervous system requires to...
Earlier studies indicate that striatal dopamine D-2 receptors are involved in pain regulation in non...