Contents

SBMLsimulator is a fast, accurate, and easily usable program for dynamic simulation and heuris-tic parameter optimization of models encoded in the Systems Biology Markup Language (SBML). In order to ensure a high reliability of this software, it has been benchmarked against the en-tire SBML Test Suite and all models from the BioModels database. It includes the large collec-tion of nature-inspired heuristic optimization procedures for efficient model calibration from the framework EvA2. SBMLsimulator provides an intuitive Graphical User Interface (GUI) and sev-eral command-line options to be suitable for large-scale batch processing and model calibration. SBMLsimulator runs on all platforms that provide a standard Java Virtual Machine and is based on the open-source library JSBML. The simulation core library of SBMLsimulator can be obtained as a separate application programming library