Towards real-time control of gene expression: controlling the HOG signaling cascade

Abstract: Motivated by experimental work in our lab, we consider here the problem of the real-time control of the expression of a single gene at the cellular level in yeast. We provide a description of the biological problem and a mathematical formulation. We develop a model predictive control strategy tailored to the specificities of the biological problem and assess in silico its effectiveness and its robustness to biological variability. 1