Coronary artery disease

• Exemption from the institutional review board was obtained • 1.5 million free text PSL diagnoses from 327,000 patients from our clinical data repository were obtained • Common free text abbreviations and synonyms were mapped to the same concept (e.g. T1DM, Type 1 diabetes mellitus, Type I diabetes) • Data were then loaded into the locally developed Molecular Concept Map (MCM) application and interesting associations were explored » Originally designed to find significant associations of co-expressed gene signatures » Performs pair-wise association analyses of all signatures » We considered each patient to be a "signature " and their problems to be the associated "expressed genes" » An all-versus-all analysis was performed » MCM provides odds ratios and p-values for associations » Network maps can also be produced Results Bicuspid aortic valve Coarctation of the aort