Actin Assembly Factors Regulate the Gelation Kinetics and Architecture of F-actin Networks

re kno d. H 1 a oss wh ha pid sten on length, cross-linking, and dynamics. The role of actin diverse actin architectures ranging from the contractile nucleation and elongation driven by physiologically rele-isoforms, Cdc12 and mDia1, were varied. Our results show formation of networks with thick bundles and large mesh6David R. Kovar and Margaret L. Gardel contributed equally to this work. Biophysical Journal Volume 104 April 2013 1709–1719 1709 2013 by the Biophysical Societysizes, whereas high nucleation rates promote a more rapid assembly of networks composed of thinner bundles and *Correspondence