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Study of large molecules (biomolecules etc) and clusters is an area of wide interest especially in atomic collision physics. The processes involved in fragmentation and ionizaion are complex and need to be investigated. Uracil is one of the four nucleobases found in RNA (Ribonucleic acid). Study of ionization and fragmentation of uracil is important to estimate the radiation damage caused by high energy ions used in cancer therapy. This energy range is the most useful range in terms of the well known Bragg peak in energy loss spectrum arising in the GeV energy particle induced cancer therapy. We have studied the ions and fragments of uracil produced by the impact of 30-80 MeV energy C and O-ion beams produced in Pelletron accelerator facility in TIFR A recoil ion ToF setup was used. The molecules, heated in an oven come out through a nozzle, forming a jet of molecules. Energy and charge state dependence of Uracil ionization has been studied. The energy dependence of absolute single ionization cross sections shows a sharp fall in this high energy range which is well reproduced by CTMC calculations [1,2] (Fig.1). In addition the charge state (q) dependence was also investigated which shows a linearly increasing trend i