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Abstract — Finite Element Method (FEM) analysis is widely used for micro-scale studies on mechanoreceptors. Previous studies primarily used two-dimensional (2D) models of the fingertip cross-sections vertical to fingerprint ridges including dermal papillae. Their results suggested that the 2D configuration of dermal papillae largely affects the stress concentration at the base of them where Merkel cells distribute. Oppositely, they barely affect Meissner corpuscles which are located at the tip of dermal papillae. Although these 2D models assume that the structure of dermal papillae is even in the third direction along fingerprint ridges, it is uneven in reality. This paper focuses on the effect of this unevenness of dermal papillae. Two types of 3D models are used. One is a model that is even along fingerprint ridges as is the case with 2D models, and the other is uneven as is the case with the real skin. This uneven model demonstrates the concentration of stress at the tip of dermal papillae. This result indicates that dermal papillae possibly enhance the response of FA-I, which is associated with Meissner corpuscles