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dynamics. This will improve our understanding of the generation and progression of diseases with stochastic and proliferative previous tissue-clearing methods, including ours, have mainly focused on homogenizing RIs, and some of them based on the lipid removal (BABB, 3DISCO, CLARITY, CUBIC, PACT-processes such as autoimmune and malignant neoplastic dis-eases, because single-cell events in these diseases eventually PARS) succeeded in the clearing and imaging of adult whole brain (Becker et al., 2012; Chung et al., 2013; Dodt et al.,gle-cell resolution by using light-sheet fluorescent microscopy. The CUBIC protocol is also applicable to 3D pathology, anatomy, and immunohistochem-istry of various organs. These results suggest that whole-body imaging of colorless tissues at high resolution will contribute to organism-level systems biology