POSTER PRESENTATION Open Access Orexinergic neurotransmission in temperature responses

Derivatives of amphetamines are widely abused all over the world. After long-term use cognitive, neurophysiologi-cal, and neuroanatomical deficits have been reported. Neurophysiological deficits are enhanced by hyperthermia, which itself is major mortality factor in drug abusers. Temperature responses to injections of methamphetamine are multiphasic and include both hypothermic and hyperthermic phases, which are highly dependent on ambient temperature and previous exposure to the drug. Also, amphetamine derivatives differentially affect various neuromediator systems, such as dopaminergic, noradre-nergic, serotonergic. Finally, body temperature is depen-dent on multiple thermoregulatory mechanisms and complex neuronal circuitry. Temperature responses to methamphetamine (Meth) a