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IgT was concomitantly discovered in trout (Oncorhynchus my-kiss) and zebrafish (Danio rerio, where it was given the appellative IgZ) and IgT or forms of Ig with IgT domains have since been de-1), functionally trapods (Mashoof l of Chines cells were fied in the epithelium of trout gill lamellae (Olsen et al., 201 clonal IgT responses were induced to trout viral pathogens et al., 2013), all further supporting the idea of this isotype fi mucosal role in teleost humoral adaptive immunity. The IgT encod-ing DH–JH–CH elements are located 50 of the l and d DH–JH–CH regions in the fish genomes in which it has been studied, with most or all VH genes 50 to the s block (Danilova et al., 2005a,b; Gambon-Deza et al., 2010; Savan et al., 2005b). Although class switc