Computationa54. Computational Neurogenetic Modeling:Gene-Dependent Dynamics of Cortexand Idiopathic Epilepsy

The chapter describes a novel computational ap-proach to modeling the cortex dynamics that integrates gene–protein regulatory networks with a neural network model. Interaction of genes and proteins in neurons affects the dynamics of the whole neural network. We have adopted an exploratory approach of investigating many ran-domly generated gene regulatory matrices out of which we kept those that generated interesting dynamics. This naïve brute force approach served us to explore the potential application of compu-tational neurogenetic models in relation to gene knock-out experiments. The knock out of a hy-pothetical gene for fast inhibition in our artificial genome has led to an interesting neural activity