Add to ORKGThe end product of drug development is the use of the drug in clinical therapy. When a drug has a narrow margin of therapeutic safety, we must steer its dosage between one that is too low, and likely to be ineffective on the one hand, or too high, and likely t
Aminoglycosides are experiencing a resurgence in use because of the spread of multiresistant Gram-ne...
Non-linearities occur no more frequently between microdose and therapeutic dose studies than in ther...
There are still a number of limitations to the full use of therapeutic drug monitoring (TDM) to opti...
Dosage regimens should generally be individualised, depending on features of the patient that can al...
Therapeutic drug monitoring (TDM) is the process by which the treatment is optimized by ensuring tha...
International audienceNowadays, guidelines are derived from the findings of randomized controlled th...
To increase the proportion of patients with successful drug treatment, dose individualisation on the...
Targeted therapies have been a major breakthrough in the treatment of cancer. With the introduction ...
e of toxicity versus serum concentration. The Therapeutic Range - Classifying the Serum Levels How...
Abstract Optimizing new drug therapies remains a challenge for clinical development, despite the use...
International audienceThe “intended purpose” in all therapeutic exposures is treatment efficacy agai...
Drug therapy is an important component of the treatment and prevention of diseases. A drug is admini...
<p>A complex system of hemostasis regulation, insufficient data on drugs pharmacokinetics, multiple ...
AbstractThe prescribed use of pharmaceuticals can result in unintended, unwelcomed, and potentially ...
BACKGROUND: : A primary goal of clinical pharmacology is to understand the factors that determine th...
Aminoglycosides are experiencing a resurgence in use because of the spread of multiresistant Gram-ne...
Non-linearities occur no more frequently between microdose and therapeutic dose studies than in ther...
There are still a number of limitations to the full use of therapeutic drug monitoring (TDM) to opti...
Dosage regimens should generally be individualised, depending on features of the patient that can al...
Therapeutic drug monitoring (TDM) is the process by which the treatment is optimized by ensuring tha...
International audienceNowadays, guidelines are derived from the findings of randomized controlled th...
To increase the proportion of patients with successful drug treatment, dose individualisation on the...
Targeted therapies have been a major breakthrough in the treatment of cancer. With the introduction ...
e of toxicity versus serum concentration. The Therapeutic Range - Classifying the Serum Levels How...
Abstract Optimizing new drug therapies remains a challenge for clinical development, despite the use...
International audienceThe “intended purpose” in all therapeutic exposures is treatment efficacy agai...
Drug therapy is an important component of the treatment and prevention of diseases. A drug is admini...
<p>A complex system of hemostasis regulation, insufficient data on drugs pharmacokinetics, multiple ...
AbstractThe prescribed use of pharmaceuticals can result in unintended, unwelcomed, and potentially ...
BACKGROUND: : A primary goal of clinical pharmacology is to understand the factors that determine th...
Aminoglycosides are experiencing a resurgence in use because of the spread of multiresistant Gram-ne...
Non-linearities occur no more frequently between microdose and therapeutic dose studies than in ther...
There are still a number of limitations to the full use of therapeutic drug monitoring (TDM) to opti...