Understanding cell proliferation mechanisms has been a long-lasting goal of the scientific community and specifically of cancer researchers. Previous genome-scale studies of cancer proliferation determinants have mainly relied on knockdown screens aimed to gauge their effects on cancer growth. This powerful approach has several limitations such as off-target effects, partial knockdown, and masking effects due to functional backups. Here we employ a complementary approach and assign each gene a cancer Proliferation Index (cPI) that quantifies the association between its expression levels and growth rate measurements across 60 cancer cell lines. Reassuringly, genes found essential in cancer gene knockdown screens exhibit significant positive ...
Gene expression profiling has identified cancer prognostic and predictive signatures with superior p...
Significant alterations in signaling pathways and transcriptional regulatory programs together repre...
Tumorigenesis is a multi-step process in which normal cells transform into malignant tumors followin...
The cancer stem cell model postulates that tumors are hierarchically organized with a minor populati...
Scripts associated with the manuscript "Identifying the genes impacted by cell proliferation in prot...
The association between cell proliferation and the malignant potential of colon cancer is not well u...
<p>(a) Violin plots showing distribution of mRNA level <i>f</i><sub><i>up</i></sub> statistic (fract...
Gene expression profiling has identified cancer prognostic and predictive signatures with superior p...
a-b) Enrichment of the proliferation signature in proteins associated with cancer stage (a) and grad...
Innovation of CRISPR gene-editing technology has provided scientists genome manipulation tools that ...
Tumour proliferation is one of the main biological phenotypes limiting cure in oncology. Extensive r...
Gene expression profiling has identified cancer prognostic and predictive signatures with superior p...
Specific combinations of transcription-factor binding sites in the promoter regions of genes regulat...
Background:Previously we demonstrated that an mRNA signature reflecting cellular proliferation had s...
<p>We grouped the genes into bins (200 genes in each bin) according to their (A) cPI and (B) nPI val...
Gene expression profiling has identified cancer prognostic and predictive signatures with superior p...
Significant alterations in signaling pathways and transcriptional regulatory programs together repre...
Tumorigenesis is a multi-step process in which normal cells transform into malignant tumors followin...
The cancer stem cell model postulates that tumors are hierarchically organized with a minor populati...
Scripts associated with the manuscript "Identifying the genes impacted by cell proliferation in prot...
The association between cell proliferation and the malignant potential of colon cancer is not well u...
<p>(a) Violin plots showing distribution of mRNA level <i>f</i><sub><i>up</i></sub> statistic (fract...
Gene expression profiling has identified cancer prognostic and predictive signatures with superior p...
a-b) Enrichment of the proliferation signature in proteins associated with cancer stage (a) and grad...
Innovation of CRISPR gene-editing technology has provided scientists genome manipulation tools that ...
Tumour proliferation is one of the main biological phenotypes limiting cure in oncology. Extensive r...
Gene expression profiling has identified cancer prognostic and predictive signatures with superior p...
Specific combinations of transcription-factor binding sites in the promoter regions of genes regulat...
Background:Previously we demonstrated that an mRNA signature reflecting cellular proliferation had s...
<p>We grouped the genes into bins (200 genes in each bin) according to their (A) cPI and (B) nPI val...
Gene expression profiling has identified cancer prognostic and predictive signatures with superior p...
Significant alterations in signaling pathways and transcriptional regulatory programs together repre...
Tumorigenesis is a multi-step process in which normal cells transform into malignant tumors followin...