Abstract. The primate visual system has an impressive ability to gen-eralize and to discriminate between numerous objects and it is robust to many geometrical transformations as well as lighting conditions. The study of the visual system has been an active reasearch field in neuropysiology for more than half a century. The construction of compu-tational models of visual neurons can help us gain insight in the process-ing of information in visual cortex which we can use to provide more robust solutions to computer vision applications. Here, we demonstrate how inspiration from the functions of shape-selective V4 neurons can be used to design trainable filters for visual pattern recognition. We call this approach COSFIRE, which stands for Comb...