Summary

Many diseases of the Central Nervous System (CNS) require treatment by novel drugs and special techniques (e.g. viral vector). However, the efficiency of the treatment may be hampered by the lack of methods to administer the drug in regions of the brain in therapeutically effective concentration range. The difficulty to deliver drugs in the brain is due to Brain Blood Barrier (BBB) that prohibits large molecules to pass through the capillary bed into the brain. Invasive drug delivery techniques aim at overcoming the BBB by directly injecting large molecules into the brain parenchyma by a catheter [1]. Recently there is interest for treating diseases of CNS with such invasive techniques. Delivery of drugs by diffusion-only does not provide effective penetration depths. On the other hand convection enhanced drug delivery has been proven effective to substantially increase the penetration depth creating a core of high concentration sufficient for many drug therapies [2]. However, there is still a need of engineering such therapies due to the lack of understanding the drug transport processes into the brain with diffusion and convection. Currently there is a lack in systematic understanding of the transport properties at cellular level and the force interactions between the fluid field and the brain tissue