Paracrine signalling Linear stability analysis

We model paracrine and autocrine signalling between breast tumor cells and macrophages. Analytical results are confirmed with discrete and continuum model simulations. Motility of breast tumor cells can be eliminated by changing certain model parameters. We identify parameters responsible for the observed tumor cell to macrophage ratio. Sensitivity of tumor cells to autocrine signalling affects their ability to migrate. a r t i c l e i n f o Article history