Integrated Simulation of Implantable Cardiac Pacemaker Software and Heart Models

Abstract: This paper presents an approach for integrated simulation of pacemaker models and heart models, each de-veloped with the appropriate formalism. Heart models are developed in MathWorks, a powerful tool for the simulation of complex systems, whereas pacemakers are developed in PVS, a theorem-proving environment enabling both simulation and formal verification of safety requirements. The two tools communicate over a Web-based interface, which makes it possible to integrate the simulation of the MathWorks model of the heart and the PVS model of the pacemaker. In this paper, we illustrate the architecture developed for integrated simulation of the pacemaker-heart system and present an example application for realistic models.