Endogenous regulatory T (Treg) cells are involved in the control of infections, including Leishmania infection in mice. Leishmania viannia braziliensis is the main etiologic agent of cutaneous leishmaniasis (CL) in Brazil, and it is also responsible for the more severe mucocutaneous form. Here, we investigated the possible in-volvement of Treg cells in the control of the immune response in human skin lesions caused by L. viannia braziliensis infection. We show that functional Treg cells can be found in skin lesions of patients with CL. These cells express phenotypic markers of Treg cells—such as CD25, cytotoxic T lymphocyte–associated antigen 4, Foxp3, and glucocorticoid-induced tumor necrosis factor receptor—and are able to produce large a...
Transforming growth factor beta (TGF-beta) has been shown to be a central immunomodulator used by le...
CD4+CD25+FOXP3+ regulatory T cells have long been shown to mediate susceptibility to Leishmania infe...
The outcome of intracellular parasitic infection can be determined by the immunoregulatory activitie...
Endogenous regulatory T (Treg) cells are involved in the control of infections, including Leishmania...
Endogenous regulatory T ( T-reg) cells are involved in the control of infections, including Leishman...
<div><h3>Background</h3><p>The inflammatory response is prominent in the pathogenesis of dermal leis...
Leishmania spp. cause a broad spectrum of diseases collectively known as leishmaniasis. Leishmania b...
International audienceThe levels of regulatory T cells (Treg cells), analyzed by Foxp3 mRNA expressi...
The levels of regulatory T cells (Treg cells), analyzed by Foxp3 mRNA expression, were determined in...
Immunopathological studies have contributed to the characterization of in situ inflammatory infiltra...
Transforming growth factor (TGF-) has been shown to be a central immunomodulator used by leish-mani...
Leishmaniasis is caused by infection with the protozoan parasite, Leishmania, that parasitizes human...
The outcome of intracellular parasitic infection can be determined by the immunoregulatory activitie...
T cell-mediated immunity is critical in resistance against Leishmania parasites, and T cell activati...
Texto completo: acesso restrito. p. 1491–1500Th1 immune responses are crucial for eliminating Leishm...
Transforming growth factor beta (TGF-beta) has been shown to be a central immunomodulator used by le...
CD4+CD25+FOXP3+ regulatory T cells have long been shown to mediate susceptibility to Leishmania infe...
The outcome of intracellular parasitic infection can be determined by the immunoregulatory activitie...
Endogenous regulatory T (Treg) cells are involved in the control of infections, including Leishmania...
Endogenous regulatory T ( T-reg) cells are involved in the control of infections, including Leishman...
<div><h3>Background</h3><p>The inflammatory response is prominent in the pathogenesis of dermal leis...
Leishmania spp. cause a broad spectrum of diseases collectively known as leishmaniasis. Leishmania b...
International audienceThe levels of regulatory T cells (Treg cells), analyzed by Foxp3 mRNA expressi...
The levels of regulatory T cells (Treg cells), analyzed by Foxp3 mRNA expression, were determined in...
Immunopathological studies have contributed to the characterization of in situ inflammatory infiltra...
Transforming growth factor (TGF-) has been shown to be a central immunomodulator used by leish-mani...
Leishmaniasis is caused by infection with the protozoan parasite, Leishmania, that parasitizes human...
The outcome of intracellular parasitic infection can be determined by the immunoregulatory activitie...
T cell-mediated immunity is critical in resistance against Leishmania parasites, and T cell activati...
Texto completo: acesso restrito. p. 1491–1500Th1 immune responses are crucial for eliminating Leishm...
Transforming growth factor beta (TGF-beta) has been shown to be a central immunomodulator used by le...
CD4+CD25+FOXP3+ regulatory T cells have long been shown to mediate susceptibility to Leishmania infe...
The outcome of intracellular parasitic infection can be determined by the immunoregulatory activitie...