Telomerase, ribonucleoprotein complex, RNA footprinting, pseudoknot ABSTRACT: The telomerase ribonucleoprotein complex ensures complete replication of eukaryotic chromosomes. Telomerase RNA, TER, provides the template for replicating the G-rich strand of telomeric DNA, provides an anchor site for telomerase-associated proteins, and participates in catalysis through several incompletely characterized mechanisms. A major impediment towards understanding its non-templating roles is the absence of high content structural information for TER within the telomerase complex. Here, we used selective 2’-hydroxyl acylation analyzed by primer extension (SHAPE) to examine the structure of Tetra-hymena TER free in solution and bound to tTERT in the minim...
Telomerase adds simple sequence repeats to the ends of linear chromosomes to counteract the loss of ...
Telomeres safeguard the genome by suppressing illicit DNA damage responses at chromosome termini. To...
Telomerase is a ribonucleoprotein complex that reverse transcribes a portion of its RNA subunit duri...
The telomerase ribonucleoprotein complex ensures complete replication of eukaryotic chromosomes. Tel...
The telomerase ribonucleoprotein complex ensures complete replication of eukaryotic chromosomes. Tel...
Telomerase is a specialized ribonucleoprotein complex that uses its RNA subunit to add six nucleotid...
Telomerase maintains telomere length at the ends of linear chromosomes using an integral telomerase ...
Telomerase is a DNA polymerase that extends the 3' ends of chromosomes by processively synthesizing ...
This dissertation consists of four projects, three focused on Nuclear Magnetic Resonance (NMR) struc...
Eukaryotic chromosomes are linear DNA strands that terminate with telomeres, protective regions of r...
abstract: In the 1970s James Watson recognized the inability of conventional DNA replication machine...
Telomerase is an enzyme that maintains telomeres, the protective structures at the ends of chromosom...
Telomerase is an RNA-protein complex comprising telomerase reverse transcriptase, a non-coding telom...
Telomerase is a ribonucleoprotein complex that counteracts the shortening of chromosome ends due to ...
Telomeres and telomerase form a dynamic interplay in order to protect the ends of eukaryotic chromos...
Telomerase adds simple sequence repeats to the ends of linear chromosomes to counteract the loss of ...
Telomeres safeguard the genome by suppressing illicit DNA damage responses at chromosome termini. To...
Telomerase is a ribonucleoprotein complex that reverse transcribes a portion of its RNA subunit duri...
The telomerase ribonucleoprotein complex ensures complete replication of eukaryotic chromosomes. Tel...
The telomerase ribonucleoprotein complex ensures complete replication of eukaryotic chromosomes. Tel...
Telomerase is a specialized ribonucleoprotein complex that uses its RNA subunit to add six nucleotid...
Telomerase maintains telomere length at the ends of linear chromosomes using an integral telomerase ...
Telomerase is a DNA polymerase that extends the 3' ends of chromosomes by processively synthesizing ...
This dissertation consists of four projects, three focused on Nuclear Magnetic Resonance (NMR) struc...
Eukaryotic chromosomes are linear DNA strands that terminate with telomeres, protective regions of r...
abstract: In the 1970s James Watson recognized the inability of conventional DNA replication machine...
Telomerase is an enzyme that maintains telomeres, the protective structures at the ends of chromosom...
Telomerase is an RNA-protein complex comprising telomerase reverse transcriptase, a non-coding telom...
Telomerase is a ribonucleoprotein complex that counteracts the shortening of chromosome ends due to ...
Telomeres and telomerase form a dynamic interplay in order to protect the ends of eukaryotic chromos...
Telomerase adds simple sequence repeats to the ends of linear chromosomes to counteract the loss of ...
Telomeres safeguard the genome by suppressing illicit DNA damage responses at chromosome termini. To...
Telomerase is a ribonucleoprotein complex that reverse transcribes a portion of its RNA subunit duri...