Tumor model identification and statistical analysis

Abstract—Tumor growth model identification under antiangio-genic therapy is a very current issue since the existing models in the literature have some limitations and usually they are not clinically validated. We have carried out animal experiments to observe valid data; mice were transplanted with C38 colon adenocarcinoma and they were treated with bevacizumab. Two groups were created, control group was treated according to the protocol, while case group members receive much lower doses daily. We created fixed and mixed models for the groups. Mixed models differs from fixed ones in random effects – in the case of mixed models both the intercept and the slope are random variables. These models are appropriate when the aim is to model not the concrete subjects in the sample, but rather, to describe the imagined population from which the samples were coming. Index Terms—tumor growth, identification, mixed model, C38 colon adenocarcinoma, bevacizuma