Relaxed cross-seeding between bacterial amyloids 1 Promiscuous cross-seeding between bacterial amyloids promotes interspecies biofilms*

highly specific. Results: Curli subunits from different bacteria can cross-seed and such interspecies interactions restore surface attachment and biofilm formation. Conclusion: Curli cross-seeding is relaxed, which promotes interspecies biofilms. Significance: This is the first study on cross-seeding of bacterial amyloids and will help define the roles of bacterial amyloids in multispecies biofilms. Amyloids are highly aggregated proteinaceous fibers historically associated with neurodegenerative conditions including Alzheimer’s, Parkinson’s and prion-base