Behavioral/Cognitive Local Morphology Predicts Functional Organization of Experienced Value Signals in the Human Orbitofrontal Cortex

Experienced value representationswithin the humanorbitofrontal cortex (OFC) are thought to be organized through an antero-posterior gradient corresponding to secondary versus primary rewards. Whether this gradient depends upon specific morphological features within this region, which displays considerable intersubject variability, remains unknown. To test the existence of such relationships, we performed a subject-by-subject analysis of fMRI data taking into account the local morphology of each individual. We tested 38 subjects engaged in a simple incentive delay task manipulating both monetary and visual erotic rewards, focusing on reward outcome (experi-enced value signal). The results showed reliable and dissociable primary (erotic) and secondary (monetary) experienced value signals at specific OFC sulci locations.More specifically, experienced value signal induced bymonetary reward outcomewas systematically located in the rostral portionof themedial orbital sulcus. Experiencedvalue signal related to erotic rewardoutcomewas locatedmoreposteriorly, that is, at the intersection between the caudal portion of themedial orbital sulcus and transverse orbital sulcus. Thus, the localizations of distinct experienced value signals can be predicted from the organization of the human orbitofrontal sulci. This study provides insights into the anatomo-functional parcellation of the anteroposterior OFC gradient observed for secondary versus primary rewards because there is a direct relationship between value signals at the time of reward outcome and unique OFC sulci locations. Key words: experienced value; fMRI; local morphology; orbitofrontal cortex; rewar