In this paper we present a supervised neural network approach to the deter-mination of photometric redshifts. The method, even though of general validity, was fine tuned to match the characteristics of the Sloan Digital Sky Survey (S-DSS) and as base of ’a priori ’ knowledge, it exploits the rich wealth of spectro-scopic redshifts provided by this unique survey. In order to train, validate and test the networks, we used two galaxy samples drawn from the SDSS spectro-scopic dataset, namely: the general galaxy sample (GG) and the luminous red galaxies subsample (LRG). Due to the uneven distribution of measured redshifts in the SDSS spectroscopic subsample, the method consists of a two steps ap-proach. In the first step, objects are classified...