Engagement of the IFN- receptor initiates multiple sig-naling cascades, including activation of the STAT. In this study, we demonstrate that IFN-, although antiprolif-erative in wild-type CD4 or CD8 T cells, act as strong mitogens on their STAT1/ counterparts. Furthermore, IFN- exert little effect on apoptosis in wild-type cells, but are potent survival factors in the absence of STAT1. The antiapoptotic response in the absence of STAT1 is predominantly mediated by STAT3, and to a lesser extent by STAT5A/B. In contrast, the mitogenic IFN- re-sponse gained through the absence of STAT1 is only mar-ginally affected when STAT5A/B expression is also abro-gated, but is completely dependent on STAT3 activation. These findings provide the firs...
<p>CD4<sup>+</sup>CD62L<sup>hi</sup>CD25<sup>-</sup> T cells were sorted from the spleens and lymph ...
IFNs are a family of cytokines that are involved in the regulation of immune and inflammatory respon...
The cytokine, Interferon (IFN)-?, induces a wide spectrum of anti-viral mediators, via the Janus kin...
Alpha/beta interferon (IFN-{alpha}/ß) triggers antiviral and antiproliferative responses in target c...
Type I IFNs are crucial cytokines of innate immunity for combating viral infections. Signaling throu...
© 2012 Dr. Nicole Louise MessinaIFNs are immunoregulatory cytokines with important roles in anti-vir...
Although Stat1 is required for many IFN-dependent responses, recent work has shown that IFN gamma fu...
STAT1 is an essential part of interferon signaling, and STAT1-deficiency results in heightened susce...
Type 1 IFNs can conditionally activate all of the signal transducers and activators of transcription...
Type I IFNs (IFN-alphabeta) enhance immune responses, notably T cell-mediated responses, in part by ...
Autocrine priming of cells by small quantities of constitutively produced type I interferon (IFN) is...
Type 1 interferons (IFNs) are induced in vivo, administered therapeutically, and potential targets f...
STAT1 is an essential part of interferon signaling, and STAT1-deficiency results in heightened susce...
Although Stat1 is essential for cells to respond fully to IFN-gamma, there is substantial evidence t...
AbstractType I IFNs induce gene expression through Stat1 and Stat2, which can in turn associate eith...
<p>CD4<sup>+</sup>CD62L<sup>hi</sup>CD25<sup>-</sup> T cells were sorted from the spleens and lymph ...
IFNs are a family of cytokines that are involved in the regulation of immune and inflammatory respon...
The cytokine, Interferon (IFN)-?, induces a wide spectrum of anti-viral mediators, via the Janus kin...
Alpha/beta interferon (IFN-{alpha}/ß) triggers antiviral and antiproliferative responses in target c...
Type I IFNs are crucial cytokines of innate immunity for combating viral infections. Signaling throu...
© 2012 Dr. Nicole Louise MessinaIFNs are immunoregulatory cytokines with important roles in anti-vir...
Although Stat1 is required for many IFN-dependent responses, recent work has shown that IFN gamma fu...
STAT1 is an essential part of interferon signaling, and STAT1-deficiency results in heightened susce...
Type 1 IFNs can conditionally activate all of the signal transducers and activators of transcription...
Type I IFNs (IFN-alphabeta) enhance immune responses, notably T cell-mediated responses, in part by ...
Autocrine priming of cells by small quantities of constitutively produced type I interferon (IFN) is...
Type 1 interferons (IFNs) are induced in vivo, administered therapeutically, and potential targets f...
STAT1 is an essential part of interferon signaling, and STAT1-deficiency results in heightened susce...
Although Stat1 is essential for cells to respond fully to IFN-gamma, there is substantial evidence t...
AbstractType I IFNs induce gene expression through Stat1 and Stat2, which can in turn associate eith...
<p>CD4<sup>+</sup>CD62L<sup>hi</sup>CD25<sup>-</sup> T cells were sorted from the spleens and lymph ...
IFNs are a family of cytokines that are involved in the regulation of immune and inflammatory respon...
The cytokine, Interferon (IFN)-?, induces a wide spectrum of anti-viral mediators, via the Janus kin...