ii

The top of the Chuwa Khola at the border between northwest Nepal and Tibet. iii In the Karnali valley of west Nepal, detailed mapping, thermobarometry, quartz-petrofabrics, vorticity analysis, and thermochronology delineate three tectonometamorphic domains separated by structural and metamorphic discontinuities. The lowest domain, the Lesser Himalayan sequence, is weakly metamorphosed and preserves evidence of primary sedimentary features and a polydeformational history. The Greater Himalayan sequence (GHS) is pervasively sheared and metamorphosed and overlies the Lesser Himalayan sequence along the Main Central thrust. The Greater Himalayan sequence is sub-divided into two tectonometamorphic domains that display contrasting metamorphic histories. The lower portion of the Greater Himalayan sequence contains garnet- to kyanite-grade rocks whose peak metamorphic assemblages developed during top-to-the-south directed shear and a metamorphic pressure gradient that increases up structural section. The upper portion of the Greater Himalayan sequence contain