C 2012 American Chemical Society Single-Particle Characterization of Aβ Oligomers in Solution

berrant aggregation of amyloido-genic proteins and peptides is asso-ciated with the pathophysiology of several diseases including Alzheimer's dis-ease, Parkinson's disease, Huntington's dis-ease, and type II diabetes mellitus.15 Although these amyloid aggregates are as-sociated with many cytotoxic effects,1 their toxic form and pathogenic mechanisms remain generally unclear.6,7 One reason for the lack in understanding is that the size and shape of amyloid oligomers are typically heterogeneous and dynamic in solution.8 Consequently, the potential toxic effects of subpopulations of oligomers i