SHORT COMMUNICATION Analycys: A Database for Conservation and Conformation of Disulphide Bonds in Homologous Protein Domains

ABSTRACT Disulphide bonds in proteins are known to play diverse roles ranging from folding to structure to function. Thorough knowledge of the conservation status and structural state of the disulphide bonds will help in understanding of the differences in homologous proteins. Here we pres-ent a database for the analysis of conservation and conformation of disulphide bonds in SCOP struc-tural families. This database has a wide range of applications including mapping of disulphide bond mutation patterns, identification of disulphide bonds important for folding and stabilization, mod-eling of protein tertiary structures and in protei