Motivation: Accurate prediction of B-cell epitopes is an important goal of computational immunology. Up to 90 % of B-cell epitopes are discontinuous in nature, yet most predictors focus on linear epitopes. Even when the tertiary structure of the antigen is available, the accurate prediction of B-cell epitopes remains challenging. Results: Our predictor, PEPITO, uses a combination of amino-acid propensity scores and half sphere exposure values at multiple distances to achieve state-of-the-art performance. PEPITO achieves an area under the curve (AUC) of 75.4 on the Discotope dataset. Additionally, we benchmark PEPITO as well as the Discotope predictor on the more recent Epitome dataset, achieving AUCs of 68.3 and 66.0, respectively
One of the major challenges in designing a peptide-based vaccine is the identification of antigenic ...
University of Technology Sydney. Faculty of Engineering and Information Technology.NO FULL TEXT AVAI...
Motivation: B-cell epitope is a small area on the surface of an antigen that binds to an antibody. A...
Motivation: Accurate prediction of B-cell epitopes is an important goal of computational immunology....
Motivation: Accurate prediction of B-cell epitopes is an important goal of computational immunology....
<div><p>The interaction between antibodies and antigens is one of the most important immune system m...
The interaction between antibodies and antigens is one of the most important immune system mechanism...
By creating antibodies against antigens, B-cells, also named B-lymphocytes, play an important role i...
By creating antibodies against antigens, B-cells, also named B-lymphocytes, play an important role i...
A B-cell epitope is the three-dimensional structure within an antigen that can be bound to the varia...
The accuracy of online tools employed in attempts to predict B-cell epitopes based on sequence are v...
Motivation: B-cell epitopes (BCEs) play a pivotal role in the development of peptide vaccines, immun...
B-cells can neutralize pathogenic molecules by targeting them with extreme specificity using recepto...
One of the major challenges in designing a peptide-based vaccine is the identification of antigenic ...
Computational prediction of discontinuous B-cell epitopes remains challenging, but it is an importan...
One of the major challenges in designing a peptide-based vaccine is the identification of antigenic ...
University of Technology Sydney. Faculty of Engineering and Information Technology.NO FULL TEXT AVAI...
Motivation: B-cell epitope is a small area on the surface of an antigen that binds to an antibody. A...
Motivation: Accurate prediction of B-cell epitopes is an important goal of computational immunology....
Motivation: Accurate prediction of B-cell epitopes is an important goal of computational immunology....
<div><p>The interaction between antibodies and antigens is one of the most important immune system m...
The interaction between antibodies and antigens is one of the most important immune system mechanism...
By creating antibodies against antigens, B-cells, also named B-lymphocytes, play an important role i...
By creating antibodies against antigens, B-cells, also named B-lymphocytes, play an important role i...
A B-cell epitope is the three-dimensional structure within an antigen that can be bound to the varia...
The accuracy of online tools employed in attempts to predict B-cell epitopes based on sequence are v...
Motivation: B-cell epitopes (BCEs) play a pivotal role in the development of peptide vaccines, immun...
B-cells can neutralize pathogenic molecules by targeting them with extreme specificity using recepto...
One of the major challenges in designing a peptide-based vaccine is the identification of antigenic ...
Computational prediction of discontinuous B-cell epitopes remains challenging, but it is an importan...
One of the major challenges in designing a peptide-based vaccine is the identification of antigenic ...
University of Technology Sydney. Faculty of Engineering and Information Technology.NO FULL TEXT AVAI...
Motivation: B-cell epitope is a small area on the surface of an antigen that binds to an antibody. A...