Evidence-based Clinical Guidelines in

Abstract. Evidence-based Clinical Guidelines are the document or rec-ommendation which follow a rigorous development process and are based on the highest quality scientific evidence. Evidence-based clinical guide-lines are important knowledge resources which have been used in many medical decision support systems and medical applications. In this pa-per, we present a semantic approach of evidence-based clinical guidelines. That lightweight formalisation of clinical guidelines have been integrat-ed with SemanticCT, a semantically-enabled system for clinical trials. We have developed several tools to generate semantic data from textual guidelines. We show how they are useful in SemanticCT for the applica-tions of the Semantic Web technology in medical domains.