Add to ORKGAbstract: Cytochrome P450 17A1 (CYP17A1) catalyses the formation and metabolism of steroid hormones. They are involved in blood pressure (BP) regulation and in the pathogenesis of left ventricular hypertrophy. Therefore, altered function of CYP17A1 due to genetic variants may influence BP and left ventricular mass. Notably, genome wide association studies supported the role of this enzyme in BP control. Against this background, we investigated associations between single nucleotide polymorphisms (SNPs) in or nearby the CYP17A1 gene with BP and left ventricular mass in patients with arterial hypertension and associated cardiovascular organ damage treated according to guidelines. Patients (n = 1007, mean age 58.0 ± 9.8 years, 83 % men) with a...
Background: Hypertension is a multifactorial disease caused by the interaction between genetic and e...
To access publisher full text version of this article. Please click on the hyperlink in Additional L...
Genome-wide association studies (GWAS) identified multiple loci for blood pressure (BP) and hyperten...
Cytochrome P450 17A1 (CYP17A1) catalyses the formation and metabolism of steroid hormones. They are...
Cytochrome P450 17A1 (CYP17A1) catalyses the formation and metabolism of steroid hormones. They are ...
OBJECTIVE: Survivors of myocardial infarction (MI) are known to have a high prevalence of arterial h...
OBJECTIVES: The aim of our study was to evaluate the relationship between aldosterone synthase gene ...
Copyright © 2015 Konstantina Bampali et al. This is an open access article distributed under the Cre...
Cardiac death remains one of the leading causes of mortality worldwide. Recent research has shed lig...
Genome-wide association studies implicate the CYP17A1 gene in human blood pressure regulation althou...
BACKGROUND: Genome-wide association studies have linked CYP17A1 coding for the steroid hormone synth...
Elevated blood pressure is a common, heritable cause of cardiovascular disease worldwide. To date, i...
OBJECTIVE: Experimental and clinical evidence supports a role of cardiotrophin-1 (CT-1) in the de...
Hypertension continues to be a major risk factor for global mortality, and recent genome-wide associ...
Background: Hypertension is a multifactorial disease caused by the interaction between genetic and e...
To access publisher full text version of this article. Please click on the hyperlink in Additional L...
Genome-wide association studies (GWAS) identified multiple loci for blood pressure (BP) and hyperten...
Cytochrome P450 17A1 (CYP17A1) catalyses the formation and metabolism of steroid hormones. They are...
Cytochrome P450 17A1 (CYP17A1) catalyses the formation and metabolism of steroid hormones. They are ...
OBJECTIVE: Survivors of myocardial infarction (MI) are known to have a high prevalence of arterial h...
OBJECTIVES: The aim of our study was to evaluate the relationship between aldosterone synthase gene ...
Copyright © 2015 Konstantina Bampali et al. This is an open access article distributed under the Cre...
Cardiac death remains one of the leading causes of mortality worldwide. Recent research has shed lig...
Genome-wide association studies implicate the CYP17A1 gene in human blood pressure regulation althou...
BACKGROUND: Genome-wide association studies have linked CYP17A1 coding for the steroid hormone synth...
Elevated blood pressure is a common, heritable cause of cardiovascular disease worldwide. To date, i...
OBJECTIVE: Experimental and clinical evidence supports a role of cardiotrophin-1 (CT-1) in the de...
Hypertension continues to be a major risk factor for global mortality, and recent genome-wide associ...
Background: Hypertension is a multifactorial disease caused by the interaction between genetic and e...
To access publisher full text version of this article. Please click on the hyperlink in Additional L...
Genome-wide association studies (GWAS) identified multiple loci for blood pressure (BP) and hyperten...