Overview of Stable Isotope Usage in Protein Labeling In

ct io n While genomic studies provide insight into the roles of DNA and gene expression in biological systems, ultimately it is the change in the concentration, localization, or identity of the effectors of biological function and proteins, that must analyzed. To this end, proteomics, which is defined as the examination of the global protein content of a biological system under specific conditions, has evolved as an invaluable tool for characterizing the complexity of living organisms. Proteomics-derived data have proven to be of interest in the identification and development of novel biomarkers for diagnostic and therapeutic applications. It has been of particular importance with regard to the characterization of differential protein levels in normal and pathophysiological states for various huma