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Cells communicate and affect each other using soluble mediators, such as cytokines and chemokines. Cytokines are proteins that orchestrate a variety of responses, including cell growth, differentiation, and effector functions, in cells that express the appropriate receptors. Cytokines are essential to the production and functions of specific T helper responses, such as Th1, Th2, Th17, Th22, T regulatory, and newly characterized Th9 and T follicular helper cells. Chemokines are a family of proteins that specifically interact with seven-transmembrane G-protein coupled receptors, inducing cell migration and homing. Fully understanding immune function and cellular responses requires the thorough examination of cytokine and chemokine profiles. BioLegend provides a variety of high quality, cost-effective ELISA kits and sets to measure cytokines, chemokines, and soluble biomarkers consistently and reliably. To view an interactive pathway on chemokine receptor biology go to: biolegend.com/chemokinebiology. Cytokines, Chemokines, and Soluble Biomarker