Clinical and biologic features predict poor prognosis in acute lymphoid leukemias in children and adolescents: a Pediatric Oncology Group review. Med Pediatr Oncol

months of age (group 2) with acute lymphoid leukemia (ALL) and of duration of continuous complete remission (CCR) for 454 in group 1 and 33 in group 2 revealed that infants fared significantly worse in both measures of out-come (P =.03 and P <.0001). To examine potential reasons for the poor prognosis of affected infants, clinical and biologic features of their ALL were compared. Infants had higher WBC counts (P <.001), a higher incidence of massive splenomegaly (P <.001), massive hepatomegaly (P <.001), more central nervous system (CNS) disease at diagnosis (P <.01), and lower platelet counts (P <.001). Also, their blasts were less often PAS (P =.02). The incidence of non(T, B, pre-B), I and pre-B immunopheno-types of ALL did not differ significantly between the two T HE PROGNOSIS of children with acute lymphoi