Coordinated control of renal Ca2+ transport proteins by parathyroid hormone

Coordinated control of renal Ca2+ transport proteins by parathyroid hormone. Background. The kidney is one of the affected organs in-volved in the clinical symptoms of parathyroid hormone (PTH)-related disorders, like primary hyperparathyroidism and famil-ial hypocalciuric hypercalcemia. The molecular mechanism(s) underlying alterations in renal Ca2+ handling in these disorders is poorly understood. Methods. Parathyroidectomized and PTH-supplemented rats and mice infused with the calcimimetic compound NPS R-467 were used to study the in vivo effect of PTH on the expres-sion of renal transcellular Ca2+ transport proteins, including the epithelial Ca2+ channel transient receptor potential, vanilloid, member 5 (TRPV5), calbindins, and the Na+/Ca2+-exchanger (NCX1). In addition, the effect of PTH on transepithelial Ca2