Editorials

Blood glucose variability in critical illness: Is it time to cast a wider net?* Alterations in glucose homeostasisare common in critical illness,even in the absence of under-lying diabetes mellitus (1). In the past, this was largely ignored or con-sidered to represent an adaptive response to critical illness. It is becoming increas-ingly obvious that stress hyperglycemia of critical illness is associated with poor outcomes (2, 3). More recently, evidence has emerged that hypoglycemia in criti-cal illness may also be independently as-sociated with poor outcomes (4, 5). A new paradigm that is being explored is the impact of blood glucose variability on outcomes from critical illness (6, 7),