COMMENTS AND RESPONSES N-of-1 (Single-Patient) Trials for Statin-Related Myalgia TO THE EDITOR: In Joy and colleagues ’ article (1), placebo and the

intervention were each administered for 3 weeks in randomized se-quences with intervening 3-week washout periods. However, prior studies suggest that statin-induced myalgia begins within weeks to months of starting therapy, with a mean period of 6 months reported in a review by Hansen and associates (2, 3). In their review, the mean period for resolution of symptoms was 2 months. Therefore, the question that arises is whether the 3-week treatment and intervening washout periods used in this study were long enough for the study participants to develop and resolve, respectively, statin-related myal-gia and/or myopathy. Visual analogue scales and a pain inventory were administered once a week during each treatment period. Recall bias thus cannot be excluded, although such bias is likely to be nondifferential for inter-vention or placebo treatment periods. Future N-of-1 trials may le-verage the availability of wireless devices for real-time reporting o