Time Horizon: Lifetime.

cluded that the harms of existing prostate-specific antigen (PSA) screening strategies outweigh the benefits. Objective: To evaluate comparative effectiveness of alternative PSA screening strategies. Design: Microsimulation model of prostate cancer incidence and mortality quantifying harms and lives saved for alternative PSA screening strategies. Data Sources: National and trial data on PSA growth, screening and biopsy patterns, incidence, treatment distributions, treatment efficacy, and mortality. Target Population: A contemporary cohort of U.S. men